Very poor live coverage of this test launch. Failed.
The rocket and spacecraft safely lifted off the pad, with the Super Heavy booster igniting all 33 of its engines. During the last attempt, multiple engines shut down prematurely.
Then, the Super Heavy booster and Starship spacecraft successfully separated, as the Starship lit up its engines and pushed away. That process ended up destroying the Super Heavy booster, which erupted into a ball of flames over the Gulf of Mexico. But the Starship spacecraft was able to briefly continue its journey.
A few minutes later, however, SpaceX was not able to regain a signal from the vehicle. And the company confirmed on its livestream that it was forced to trigger Starship's self-destruct feature.